Time-trends in gastroprotection with nonsteroidal anti-inflammatory drugs (NSAIDs)
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چکیده
منابع مشابه
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Derivatives with Anti-Cancer Activity
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a diverse class of drugs commonly used for the treatment of inflammatory conditions, have been found to be highly effective in preventing and treating many types of cancers. However, toxicity from cyclooxygenase (COX) inhibition and the suppression of physiologically important prostaglandins limits their use for cancer chemoprevention and prompt...
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BACKGROUND Gastroprotective agents (GPA) substantially reduce morbidity and mortality with long-term nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin. OBJECTIVE To evaluate efficacy of NSAIDs, protection against NSAID-induced gastrointestinal harm, and balance of benefit and risk. METHODS Free text searches of PubMed (December 2012) supplemented with "related citation" and "cited b...
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Randall Harris, of Ohio State University, Columbus, Ohio, and colleagues presented very interesting results from a prospective study on the effects of anti-inflammatory agents in the chemoprevention of breast cancer in women enrolled in the Women's Health Initiative observational study. A total of 80,741 postmenopausal women (50-79 years of age) with no previous history of cancer (other than no...
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Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
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It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2010
ISSN: 0269-2813,1365-2036
DOI: 10.1111/j.1365-2036.2010.04281.x